A DNA repair-independent role for alkyladenine DNA glycosylase in alkylation-induced unfolded protein response

• Jerry Martin

Alkylating brokers harm DNA and proteins and are extensively utilized in most cancers chemotherapy. Whereas mobile responses to alkylation-induced DNA harm have been explored, information of how alkylation impacts world mobile stress responses is sparse. Right here, we examined the results of the alkylating agent methylmethane sulfonate (MMS) on gene expression in mouse liver, utilizing…