A DNA repair-independent role for alkyladenine DNA glycosylase in alkylation-induced unfolded protein response
Doable Advantages of a Low Protein Weight loss program in Older Sufferers With CKD at Danger of Malnutrition: A Pilot Randomized Managed Trial
p53-mediated neurodegeneration within the absence of the nuclear protein Akirin2
Correct gene regulation is vital for each neuronal improvement and upkeep because the mind matures. We beforehand demonstrated that Akirin2, an important nuclear protein that interacts with transcription components and chromatin transforming complexes, is required for the embryonic formation of the cerebral cortex. Right here we present that Akirin2 performs a mechanistically distinct function in sustaining wholesome neurons throughout cortical maturation. Limiting Akirin2 loss to excitatory cortical neurons resulted in progressive neurodegeneration by way of necroptosis and extreme cortical atrophy with age.
Evaluating transcriptomes from Akirin2-null postnatal neurons and cortical progenitors revealed that targets of the tumor suppressor p53, a regulator of each proliferation and cell demise encoded by Trp53, have been persistently upregulated. Discount of Trp53 rescued neurodegeneration in Akirin2-null neurons. These knowledge:
- (1) implicate Akirin2 as a vital neuronal upkeep protein,
- (2) establish p53 pathways as mediators of Akirin2 features, and
- (3) recommend Akirin2 dysfunction could also be related to neurodegenerative ailments.
Bodily Properties of Peanut and Soy Protein-Based mostly Emulsion Gels Induced by Varied Coagulants
An replace of label-free protein goal identification strategies for pure energetic merchandise
The Intriguing Panorama of Single-Cell Protein Evaluation
339 Protein A 1 mg |
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339 | YO Proteins AB | 1 mg | 157.3 EUR |
857 Protein G - HRP conjugate 1 mg |
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857 | YO Proteins AB | 1 mg | 315.7 EUR |
545 Rabbit anti-human IgA polyclonal antibody FITC 1.2 mg |
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545 | YO Proteins AB | 1.2 mg | 315.7 EUR |
445 Mouse anti-human IgM monoclonal antibody, clone ICL-931 0.5 ml |
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445 | YO Proteins AB | 1 ml | 157.3 EUR |
447 Mouse anti-human Apolipoprotein B monoclonal antibody, clone 12G10 1 ml |
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447 | YO Proteins AB | 1 ml | 382.8 EUR |
574 Monoclonal mouse antibody anti-human IgM clone ICL-931 FITC 1 ml |
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574 | YO Proteins AB | 1 ml | 315.7 EUR |
576 Collagen type III (bovine, atelocollagen suitable for 3D gel, sterile, lyophilized) |
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576 | YO Proteins AB | 10 mg | 382.8 EUR |
562-100 Monoclonal mouse antibody anti-taq polymerase 100 mg |
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562-100 | YO Proteins AB | 100 mg | 4004 EUR |
596 Sheep anti-rabbit IgG, IgM, IgA polyclonal antibody 1 mg |
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596 | YO Proteins AB | 1 mg | 247.5 EUR |
605 Rabbit anti-human alpha fetoprotein polyclonal antibody 1 mg |
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605 | YO Proteins AB | 0.1 mg | 382.8 EUR |
840 Urokinase human 20 ug |
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840 | YO Proteins AB | 20 ug | 218.9 EUR |