Concavalin A

Concanavalin A Hepatitis plant lectin

Concanavalin A (Con A) is a plant lectin that is purified from jack beans. Con A binds to the mannose residues of varied glycoproteins and prompts lymphocytes. When Con A is run to mice, liver injury that can depend upon the activation of T lymphocytes by macrophages occurs (Tiegs et al., 1992). As a result of this reality, the model could allow the study of the pathophysiology of immunologically mediated hepatic points, resembling AIH. TNF-α and IFN-γ play important roles in Con A–induced liver injury (Gantner et al., 1995; Kusters et al., 1996) and IL-10 prevents liver injury on this model (Di Marco et al., 1999; Louis et al., 1997). Blood ranges of IL-2, IL-4, and IFN-γ dramatically improve after administration of Con A (Wang et al., 2012). Essential drawbacks of this model embrace the dearth of circulating autoantibodies and quick hepatocyte damage following a single-dose Con A injection, which is not a typical attribute of persistent AIH.

 

Lectins as modulators of autophagy in most cancers immunotherapy

Concanavalin A prompts T cells and pure killer cells and triggers anticancer immune responses

Since ConA is a well-known T cell mitogen it would moreover set off anticancer immune responses by activating tumor specific CTLs. Actually, remedy of hepatoma-bearing mice (ML-14a cells) with ConA (7.5 mg/kg) strongly diminished liver tumor formation and prolonged survival, whereby 40% of the animals had been tumor free on the end of the experiment [8]. Lymphocytic infiltrates spherical tumor nodules had been seen in ConA-treated animals, suggesting T cell mediated responses. Actually, the depletion of CD8+ T cells completely abrogated the therapeutic outcomes of ConA, whereas the depletion of CD4+ T cells solely partly prevented ConA-mediated inhibition of tumor formation (Fig. 4A). In line with this study, ConA triggered CD4+ and CD8+ T cell activation in mice as confirmed by the upregulated expression of CD69 [74].

In addition to, ConA-treated mice contained elevated numbers of activated pure killer (NK) cells, T cells, and NK T cells, which confirmed sturdy cytotoxic train in opposition to murine lymphoma cells in ex vivo assays. That’s moreover translated proper right into a strongly diminished number of liver nodules upon ConA remedy of colon cancer-bearing mice (colon-26), an affect that was abrogated upon NK cell depletion (Fig. 4A). Of observe, NK cells in immunodeficient nude mice (lacking NKT and T cells) weren’t activated upon ConA remedy, suggesting a job of the adaptive immune system in activating NK cells [74].

Concavalin A
Concavalin A

Furthermore, all outcomes had been abrogated in IFNγ knock-out mice, displaying the importance of an full of life immune response. Nonetheless, the remedy with ConA of hepatoma-bearing SCID mice moreover significantly inhibited liver tumor formation, nevertheless solely on the best dose of 20 mg/kg [8]. As SCID mice lack purposeful lymphocytes, these info counsel a direct cytotoxic affect of ConA in the direction of the most cancers cells. Actually, ConA induced direct autophagy-dependent cell demise in these mice (see above paragraph about ConA and most cancers cell demise). Thus, ConA prompts CD8+ CTLs and NK cells that in the reduction of in vivo tumor progress and potentiate ex vivo tumor cell lysis (Fig. 4A).

 

Recombinant Xenopus tropicalis 60S ribosomal protein L36 (rpl36)

CSB-EP728513XBF 10268 mg Ask for price

Recombinant Xenopus tropicalis Akirin-1 (akirin1)

CSB-EP682578XBF 7428 mg Ask for price

Recombinant Xenopus tropicalis Transcription factor Sox-1 (sox1)

CSB-EP022417XBF 6881 mg Ask for price

Recombinant Xenopus tropicalis Hyaluronan synthase 1 (has1), partial

CSB-EP010139XBF1 10342 mg Ask for price

Recombinant Human Programmed cell death protein 10 (PDCD10)

CSB-EP861141HU 4508 mg Ask for price

Recombinant Human Programmed cell death protein 10(PDCD10)

AP71511 1mg
EUR 1978

Recombinant Programmed Cell Death Protein 1 (PD1)

RPU53502-100ug 100ug
EUR 554.4

Recombinant Programmed Cell Death Protein 1 (PD1)

RPU53502-1mg 1mg
EUR 2457

Recombinant Programmed Cell Death Protein 1 (PD1)

RPU53502-50ug 50ug
EUR 445.5

Recombinant Programmed Cell Death Protein 1 (PD1)

RPU53816-100ug 100ug
EUR 564.3

Recombinant Programmed Cell Death Protein 1 (PD1)

RPU53816-1mg 1mg
EUR 2501.2

Recombinant Programmed Cell Death Protein 1 (PD1)

RPU53816-50ug 50ug
EUR 453.2

Recombinant Programmed Cell Death Protein 1 (PD1)

RPU58652-100ug 100ug
EUR 604.8

Recombinant Programmed Cell Death Protein 1 (PD1)

RPU58652-1mg 1mg
EUR 2808

Recombinant Programmed Cell Death Protein 1 (PD1)

RPU58652-50ug 50ug
EUR 470.3

Recombinant Programmed Cell Death Protein 1 (PD1)

RPA751Ca01 10ug
EUR 199

Recombinant Programmed Cell Death Protein 1 (PD1)

RPA751Hu01 10ug
EUR 183

Recombinant Programmed Cell Death Protein 1 (PD1)

RPA751Hu02 10ug
EUR 180

Recombinant Programmed Cell Death Protein 1 (PD1)

RPA751Mu01 10ug
EUR 187

Recombinant Programmed Cell Death Protein 1 (PD1)

RPA751Ra01 10ug
EUR 180

Recombinant Programmed Cell Death Protein 5 (PDCD5)

RPU52490-100ug 100ug
EUR 528

Recombinant Programmed Cell Death Protein 5 (PDCD5)

RPU52490-1mg 1mg
EUR 2337.4

Recombinant Programmed Cell Death Protein 5 (PDCD5)

RPU52490-50ug 50ug
EUR 423.5

Recombinant Programmed Cell Death Protein 6 (PDCD6)

RPU53272-100ug 100ug
EUR 542.3

Recombinant Programmed Cell Death Protein 6 (PDCD6)

RPU53272-1mg 1mg
EUR 2402.4

Recombinant Programmed Cell Death Protein 6 (PDCD6)

RPU53272-50ug 50ug
EUR 435.6

Recombinant Programmed Cell Death Protein 1 (PDCD1)

4-RPA751Hu01
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Programmed Cell Death Protein 1 expressed in: E.coli

Recombinant Programmed Cell Death Protein 1 (PDCD1)

4-RPA751Ra01
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Programmed Cell Death Protein 1 expressed in: E.coli

Recombinant Programmed Cell Death Protein 6 (PDCD6)

RPL096Hu01 10ug
EUR 176

Recombinant Programmed Cell Death Protein 6 (PDCD6)

4-RPL096Hu01
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Programmed Cell Death Protein 6 expressed in: E.coli

Recombinant Programmed Cell Death Protein 5 (PDCD5)

RPL105Hu01 10ug
EUR 171

Recombinant Programmed Cell Death Protein 5 (PDCD5)

4-RPL105Hu01
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Programmed Cell Death Protein 5 expressed in: E.coli
Jerry Martin