
Concanavalin A Hepatitis plant lectin
Concanavalin A (Con A) is a plant lectin that is purified from jack beans. Con A binds to the mannose residues of varied glycoproteins and prompts lymphocytes. When Con A is run to mice, liver injury that can depend upon the activation of T lymphocytes by macrophages occurs (Tiegs et al., 1992). As a result of this reality, the model could allow the study of the pathophysiology of immunologically mediated hepatic points, resembling AIH. TNF-α and IFN-γ play important roles in Con A–induced liver injury (Gantner et al., 1995; Kusters et al., 1996) and IL-10 prevents liver injury on this model (Di Marco et al., 1999; Louis et al., 1997). Blood ranges of IL-2, IL-4, and IFN-γ dramatically improve after administration of Con A (Wang et al., 2012). Essential drawbacks of this model embrace the dearth of circulating autoantibodies and quick hepatocyte damage following a single-dose Con A injection, which is not a typical attribute of persistent AIH.
Lectins as modulators of autophagy in most cancers immunotherapy
Concanavalin A prompts T cells and pure killer cells and triggers anticancer immune responses
Since ConA is a well-known T cell mitogen it would moreover set off anticancer immune responses by activating tumor specific CTLs. Actually, remedy of hepatoma-bearing mice (ML-14a cells) with ConA (7.5 mg/kg) strongly diminished liver tumor formation and prolonged survival, whereby 40% of the animals had been tumor free on the end of the experiment [8]. Lymphocytic infiltrates spherical tumor nodules had been seen in ConA-treated animals, suggesting T cell mediated responses. Actually, the depletion of CD8+ T cells completely abrogated the therapeutic outcomes of ConA, whereas the depletion of CD4+ T cells solely partly prevented ConA-mediated inhibition of tumor formation (Fig. 4A). In line with this study, ConA triggered CD4+ and CD8+ T cell activation in mice as confirmed by the upregulated expression of CD69 [74].
In addition to, ConA-treated mice contained elevated numbers of activated pure killer (NK) cells, T cells, and NK T cells, which confirmed sturdy cytotoxic train in opposition to murine lymphoma cells in ex vivo assays. That’s moreover translated proper right into a strongly diminished number of liver nodules upon ConA remedy of colon cancer-bearing mice (colon-26), an affect that was abrogated upon NK cell depletion (Fig. 4A). Of observe, NK cells in immunodeficient nude mice (lacking NKT and T cells) weren’t activated upon ConA remedy, suggesting a job of the adaptive immune system in activating NK cells [74].

Furthermore, all outcomes had been abrogated in IFNγ knock-out mice, displaying the importance of an full of life immune response. Nonetheless, the remedy with ConA of hepatoma-bearing SCID mice moreover significantly inhibited liver tumor formation, nevertheless solely on the best dose of 20 mg/kg [8]. As SCID mice lack purposeful lymphocytes, these info counsel a direct cytotoxic affect of ConA in the direction of the most cancers cells. Actually, ConA induced direct autophagy-dependent cell demise in these mice (see above paragraph about ConA and most cancers cell demise). Thus, ConA prompts CD8+ CTLs and NK cells that in the reduction of in vivo tumor progress and potentiate ex vivo tumor cell lysis (Fig. 4A).
![]() Programmed Cell Death Protein 10 (PDCD10) Antibody |
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abx236237-100ug | Abbexa | 100 ug | EUR 577.2 |
![]() Programmed Cell Death Protein 10 (PDCD10) Antibody |
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20-abx214660 | Abbexa |
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![]() Human Programmed cell death protein 10 (PDCD10) |
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1-CSB-EP861141HU | Cusabio |
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Description: Recombinant Human Programmed cell death protein 10(PDCD10) expressed in E.coli |
![]() Programmed Cell Death Protein 10 (PDCD10) Antibody (HRP) |
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20-abx310611 | Abbexa |
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![]() Programmed Cell Death Protein 10 (PDCD10) Antibody (FITC) |
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20-abx310612 | Abbexa |
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![]() Programmed Cell Death Protein 10 (PDCD10) Antibody (Biotin) |
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20-abx310613 | Abbexa |
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![]() Human Programmed Cell Death Protein 10 (PDCD10) ELISA Kit |
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abx382112-96tests | Abbexa | 96 tests | EUR 1093.2 |
![]() Chicken Programmed cell death protein 10, PDCD10 ELISA KIT |
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ELI-35614c | Lifescience Market | 96 Tests | EUR 1113.6 |
![]() Human Programmed cell death protein 10, PDCD10 ELISA KIT |
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ELI-20923h | Lifescience Market | 96 Tests | EUR 988.8 |
![]() Mouse Programmed cell death protein 10, Pdcd10 ELISA KIT |
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ELI-14591m | Lifescience Market | 96 Tests | EUR 1038 |
![]() Programmed Cell Death 5 Protein |
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20-abx262104 | Abbexa |
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![]() Programmed Cell Death 6 Protein |
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20-abx262735 | Abbexa |
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20-abx262858 | Abbexa |
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![]() Recombinant Programmed Cell Death Protein 6 (PDCD6) |
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4-RPL096Hu01 | Cloud-Clone |
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Description: Recombinant Human Programmed Cell Death Protein 6 expressed in: E.coli |
![]() Recombinant Programmed Cell Death Protein 5 (PDCD5) |
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4-RPL105Hu01 | Cloud-Clone |
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Description: Recombinant Human Programmed Cell Death Protein 5 expressed in: E.coli |
![]() Recombinant Programmed Cell Death Protein 1 (PDCD1) |
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4-RPA751Hu01 | Cloud-Clone |
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Description: Recombinant Human Programmed Cell Death Protein 1 expressed in: E.coli |
![]() Recombinant Programmed Cell Death Protein 1 (PDCD1) |
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4-RPA751Ra01 | Cloud-Clone |
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Description: Recombinant Rat Programmed Cell Death Protein 1 expressed in: E.coli |
![]() Recombinant Human Programmed Cell Death 5 |
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7-05830 | CHI Scientific | 5µg | Ask for price |
![]() Recombinant Human Programmed Cell Death 5 |
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7-05831 | CHI Scientific | 20µg | Ask for price |
![]() Recombinant Human Programmed Cell Death 5 |
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7-05832 | CHI Scientific | 1mg | Ask for price |
![]() Recombinant Human Programmed Cell Death 6 |
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7-05833 | CHI Scientific | 2µg | Ask for price |
![]() Recombinant Human Programmed Cell Death 6 |
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7-05834 | CHI Scientific | 10µg | Ask for price |
![]() Recombinant Human Programmed Cell Death 6 |
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7-05835 | CHI Scientific | 1mg | Ask for price |
![]() Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-100ug |
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QP8043-ec-100ug | EnQuireBio | 100ug | EUR 489.6 |
![]() Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-10ug |
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QP8043-ec-10ug | EnQuireBio | 10ug | EUR 240 |
![]() Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-1mg |
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QP8043-ec-1mg | EnQuireBio | 1mg | EUR 1958.4 |
![]() Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-200ug |
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QP8043-ec-200ug | EnQuireBio | 200ug | EUR 760.8 |
![]() Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-500ug |
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QP8043-ec-500ug | EnQuireBio | 500ug | EUR 1272 |
![]() Recombinant Human Programmed cell death protein 10 Protein, His-SUMO, E.coli-50ug |
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QP8043-ec-50ug | EnQuireBio | 50ug | EUR 315.6 |
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20-abx260576 | Abbexa |
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![]() PDCD1/Programmed cell death protein 1 |
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E21-D91 | EnoGene | 10ug | EUR 411.6 |
![]() PDCD5 Programmed Cell Death-5 Human Recombinant Protein |
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PROTO14737 | BosterBio | Regular: 20ug | EUR 380.4 |
Description: PDCD5 Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 125 amino acids and having a molecular mass of 14 kDa. |