bioinfor

Applying behavioural science to increase uptake

Making use of behavioural science to extend uptake of the NHS Well being Verify: a randomised managed trial of gain- and loss-framed messaging within the nationwide affected person data leaflet.

  • The NHS Well being Verify (NHSHC) is a nationwide programme for the prevention of non-communicable ailments. Sufferers aged 40-74 with out an current cardiovascular-related situation ought to be invited quinquennially. Uptake is decrease than anticipated. We assessed the influence on uptake of two new behaviourally-enhanced leaflets (with the present nationwide leaflet as a management), enclosed with the invitation letter: the primary trial on the leaflet.A double-blind three-armed randomized managed trial was performed. The brand new leaflets had been shorter (two pages, as a substitute of 4); one was loss-framed (‘do not miss out’) and the opposite was gain-framed (‘benefit from life’).
  • The individuals had been sufferers from 39 practices in Lewisham and 17 practices in NE Lincolnshire, who had been allotted to interventions utilizing a random-number generator and obtained one of many leaflets with their invitation letter from April-September 2018. The result measure was uptake of an NHSHC by November 2018. The trial was powered to detect a 2% impact.Uptake was 17.6% within the management situation (n = 3677), 17.4% within the loss-framed situation (n = 3664), and 18.2% within the gain-framed situation (n = 3697). Leaflet kind was not a major predictor of NHSHC uptake in a logistic regression that managed for demographic variables, with GP observe as a random impact. Statistically important predictors of uptake included location (increased uptake in Lewisham), age (elevated age was related to elevated attendance) and intercourse (increased uptake in females).
  • The Bayes Issue evaluating the null to a speculation of variations between situations was 416, which is excessive proof in favour of the null speculation.There was no proof for a significant impact of both a loss-framed or gain-framed behaviourally-informed leaflet kind on uptake, which is shocking, provided that behaviourally knowledgeable letters have improved uptake of NHSHCs. It’s attainable that individuals don’t take note of leaflets which are enclosed with letters, or that the leaflet continues to help knowledgeable decision-making however this doesn’t have an effect on uptake.Clinicaltrials.gov, NCT03524131. Registered Could 14, 2018. Retrospectively registered.
bioinfor
bioinfor

Poisoning attributable to family merchandise: A ten years retrospective evaluation of phone calls to the Nationwide Poisons Info Centre, All India Institute of Medical Sciences, New Delhi, India.

Intensive use of various chemical substances in numerous fields and their straightforward availability has led to an elevated incidence of unintentional and intentional poisoning in growing international locations together with India. A various vary of family merchandise generally used for home functions comprise pesticides, family cleaners, thermometer mercury, antiseptics, kerosene, paint thinners and so forth. Any of those merchandise, if misused or mishandled may cause poisoning. In India, the Nationwide Poisons Centre (NPIC) on the All India Institute of Medical Sciences, New Delhi, supplies data on administration of poisoning to treating physicians. Evaluation of information based mostly on phone calls obtained by the NPIC (April 2006-March 2016) has highlighted a excessive incidence of poisoning attributable to family merchandise, adopted by prescription drugs, agricultural pesticides and industrial chemical substances.
The target of the current retrospective examine was to find out the incidence of poisoning attributable to numerous family merchandise as reported to the NPIC in the course of the ten years interval. The entire variety of calls obtained by the Centre was 16,420. There have been 7114 calls (45.5%) attributable to family merchandise with adults (>18yrs.) and youngsters (<1-18yrs.) constituting 38.7% and 61.2% calls respectively. Males outnumbered females (M = 62.4%, F = 37.5%). The mode of poisoning was primarily unintentional (66.8%) adopted by intentional mode (33.2%). The most common route of publicity was oral (95.6%). Family pesticides had been generally implicated (43.7%) adopted by family cleaners (21.8%), thermometer mercury (5.2%) naphthalene balls (5%), antiseptics (3%), kerosene (2%) and paint thinner (2%). Miscellaneous merchandise comprising of camphor, silica gel, hair dye, nail polish remover, cosmetics, adhesives and so forth had been additionally concerned in poisoning (17.1%). The pattern and sample of poisoning varies in numerous elements of the nation, as a result of all calls on poisoning usually are not reported to the Centre.
So the information as such will not be a real reflection of the situation in India. Nonetheless, the outcomes do point out an growing incidence of poisoning attributable to family merchandise particularly in youngsters. The possible causes for prime incidence might be careless storage, ignorance, non compliance with prescribed directions to be used and negligible parental supervision in case of kids. The outcomes of the examine spotlight, an pressing have to determine excessive threat circumstances, widespread poisonous merchandise concerned and implementation of prevention and consciousness programmes, to attain poisons management at house.

Pesticide poisoning pattern evaluation of 13 years: a retrospective examine based mostly on phone calls on the Nationwide Poisons Info Centre, All India Institute of Medical Sciences, New Delhi.

  • The examine was designed to investigate the incidence and sample of pesticide poisoning calls reported to the Nationwide Poisons Info Centre (NPIC), AIIMS, New Delhi and spotlight the widespread lessons of pesticides concerned in poisoning. The phone calls obtained by the Centre in the course of the 13 12 months interval (1999-2012) had been entered right into a preset proforma after which right into a retrievable database. A complete of 4929 calls of pesticide poisoning had been recorded. The information was analyzed with respect to age, gender, mode and sort of poisoning. The age ranged from 1 to 65 years with the preponderance of males (M = 62.19%, F = 37.80%).
  • The age group primarily concerned in poisoning was 18-35 years. Whereas 59.38% calls pertained to family pesticides, 40.61% calls associated to agricultural pesticides. The widespread mode of poisoning was intentional (64.60%) adopted by unintentional (34.40%) and unknown (1%).
  • Amongst the family pesticides, the best variety of calls had been attributable to pyrethroids (26.23%) adopted by rodenticides (17.06%), organophosphates (6.26%), carbamates (4.95%) and others (4.86%). In agricultural pesticides group, the organophosphates (9.79%) ranked the primary adopted by, aluminium phosphide (9.65%), organochlorines (9.31%), pyrethroids (3.87%), herbicides, weedicides and fungicides (3.20%), ethylene dibromide (2.82%), and others (1.70%). The information evaluation reveals a excessive incidence of poisoning attributable to family pesticides as in comparison with agricultural pesticides, clearly emphasizing the necessity for creating consciousness and training about correct use and implementation of prevention programmes.

Speaking immunization science: the genesis and evolution of the Nationwide Community for Immunization Info.

For 10 years, the Nationwide Community for Immunization Info (NNii) has pursued its purpose to “present the general public, well being professionals, coverage makers, and the media with up-to-date, scientifically legitimate data associated to immunizations to assist them perceive the problems and to make knowledgeable selections.” This investigation supplies a essential analysis of the strategic communication planning and implementation of NNii from conception to current day. The examine makes use of a case examine methodology, growing a scientific evaluation of organizational paperwork, the media atmosphere, and in-depth interviews by making use of Weick’s mannequin of organizing as an interpretive framework. Iterative information evaluation included open coding, axial coding, and thematic saturation.
Themes had been in contrast with phases of strategic communication and current examine propositions. Main themes recognized included the group’s informative nature, funding credibility, nonbranding, reflective analysis, collaborative partnerships, and media technique. NNii meets the necessities of requisite selection, nonsummativity, and organizational flexibility proposed by Weick’s mannequin of organizing. Nonetheless, an absence of systematic analysis of group targets prevents it from adapting communication ways and methods. As well as, the authors advocate that NNii, whereas sustaining its informative nature, undertake persuasive methods to draw and retain the eye of its goal audiences.

Mouse LIF ELISA Kit

EML0014 96Tests
EUR 625.2

Mouse LIF shRNA Plasmid

20-abx971321
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Recombinant Mouse LIF Protein

R01400-1 100ug/vial
EUR 352.8

ELISA kit for Mouse LIF

EK5250 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse LIF in samples from serum, plasma, tissue homogenates and other biological fluids.

Mouse LIF PicoKine ELISA Kit

EK0580 96 wells
EUR 510
Description: For quantitative detection of mouse LIF in cell culture supernates, serum and plasma (heparin, EDTA).

Lif ORF Vector (Mouse) (pORF)

ORF049145 1.0 ug DNA
EUR 607.2

Lif ORF Vector (Mouse) (pORF)

ORF049146 1.0 ug DNA
EUR 607.2

LIF ELISA Kit (Mouse) (OKBB00760)

OKBB00760 96 Wells
EUR 606
Description: Description of target: Leukemia inhibitory factor, or LIF, is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation. When LIF levels drop, the cells differentiate. The LIF was mapped gene to 22q11-q12.2 by Southern analysis of a series of mouse/human somatic cell hybrids and by in situ hybridization to the chromosomes of 2 normal males and some individuals with chromosomal rearrangements. The gene maps between the Philadelphia translocation BCR1 and the breakpoint of the translocation in cell line GM2324 at 22q12.2. LIF derives its name from its ability to induce the terminal differentiation of myeloid leukemic cells, thus preventing their continued growth. Other properties attributed to the cytokine include: the growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: <10pg>

LIF ELISA Kit (Mouse) (OKEH04045)

OKEH04045 96 Wells
EUR 652.8
Description: Description of target: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.039 ng/mL

LIF, Mouse Recombinant , 1MIU/ml

L4500-001 1ml
EUR 406.8

LIF, Mouse Recombinant , 1MIU/ml

L4500-005 5x1ml
EUR 1431.6

LIF, Mouse Recombinant , 10MIU/ml

L4501-001 1ml
EUR 1744.8

Nori® Mouse LIF ELISA Kit

GR117058 96-well
EUR 461

Human CellExp? LIF, mouse recombinant

7268-10 each
EUR 444

Leukemia Inhibitory Factor (LIF), mouse

PR16102 5 ug
EUR 522

Lif sgRNA CRISPR Lentivector set (Mouse)

K3872501 3 x 1.0 ug
EUR 406.8

LIF Antibody

25283-100ul 100ul
EUR 468

LIF Antibody

6245-002mg 0.02 mg
EUR 206.18
Description: LIF Antibody: LIF is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. LIF was initially recognized by its ability to induce terminal differentiation of myeloid leukemic cells. It is a member of the IL-6 cytokine superfamily and can be highly glycosylated. LIF signaling is transduced through the LIF-R/gp130 receptor complex, leading to the phosphorylation and activation of the JAK/STAT pathway. Recent evidence shows that LIF inhibits cardiomyogenesis in embryonic stem cells via STAT3 activation.

LIF Antibody

6245-01mg 0.1 mg
EUR 523.7
Description: LIF Antibody: LIF is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. LIF was initially recognized by its ability to induce terminal differentiation of myeloid leukemic cells. It is a member of the IL-6 cytokine superfamily and can be highly glycosylated. LIF signaling is transduced through the LIF-R/gp130 receptor complex, leading to the phosphorylation and activation of the JAK/STAT pathway. Recent evidence shows that LIF inhibits cardiomyogenesis in embryonic stem cells via STAT3 activation.

LIF antibody

70R-12299 100 ug
EUR 483.6
Description: Rabbit polyclonal LIF antibody

LIF antibody

70R-14100 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal LIF antibody

LIF antibody

70R-6230 50 ug
EUR 560.4
Description: Rabbit polyclonal LIF antibody

LIF antibody

70R-51295 100 ul
EUR 292.8
Description: Purified Polyclonal LIF antibody

LIF Antibody

36950-100ul 100ul
EUR 302.4

LIF Antibody

5216-100 each
EUR 379.2

LIF Antibody

5216-30T each
EUR 175.2

LIF Antibody

1-CSB-PA004761
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against LIF. Recognizes LIF from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000

LIF Antibody

1-CSB-PA198481
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against LIF. Recognizes LIF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:10000, IHC:1:25-1:100

LIF Antibody

DF13730 100ul
EUR 420

LIF Antibody

1-CSB-PA012928ESR2HU
  • EUR 266.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against LIF. Recognizes LIF from Human. This antibody is Unconjugated. Tested in the following application: ELISA

LIF Antibody

F49998-0.08ML 0.08 ml
EUR 140.25
Description: LIF is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface.

LIF Antibody

F49998-0.4ML 0.4 ml
EUR 322.15
Description: LIF is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface.