bioinfor

Knowledge and utilization of the United States National Library

Information and utilization of the US Nationwide Library of Drugs’s biomedical info services amongst African well being sciences librarians.

The United States Nationwide Library of Drugs (NLM) has the biggest assortment of biomedical info services on this planet. Little is thought of the extent to which librarians in sub-Saharan Africa are conscious of and use these assets. The research’s purpose was to evaluate information and frequency of use of NLM’s biomedical info services amongst African librarians. Forty-three of the 50 delegates on the 11th biannual Congress of the Affiliation of Well being Info and Libraries in Africa (AHILA) participated within the research. The findings confirmed that members’ information of NLM info services was low and that there’s a want for elevated consciousness and coaching in the usage of NLM’s info services to ensure that customers on the African continent to successfully profit from them.

Why there may be no sustainable nationwide healthcare IT program with no translational well being info science.

Well being info expertise analysis has traditionally suffered from the persistence of paper-based programs as a barrier to analysis and refinement of knowledge fashions. Whereas the sphere of (non-medical) info science provides a probably wealthy supply of knowledge, there exist comparatively few theoretical hyperlinks between medical and non-medical info fashions. This paper argues that the institution of an built-in translational analysis pathway just isn’t solely helpful, however is a important and obligatory step within the realization of a nationwide well being info infrastructure within the USA.
bioinfor
bioinfor

An epidemiological research of poisoning circumstances reported to the Nationwide Poisons Info Centre, All India Institute of Medical Sciences, New Delhi.

  • A retrospective evaluation of poisoning calls acquired by the Nationwide Poisons Info Centre confirmed a complete of 2719 calls over a interval of three years (April 1999-March 2002). The queries have been made on poisoning administration (92%) and data (8%) about varied merchandise and functioning of the centre. The info have been analysed with respect to age, intercourse, mode and sort of poisoning. The brokers belonged to numerous teams: family merchandise, agricultural pesticides, industrial chemical substances, medication, vegetation, animal bites and stings, miscellaneous and unknown teams respectively. The age ranged from lower than 1 to 70 years, with the very best incidence within the vary of 14-40 years, with males (57%) outnumbering females (43%).
  • The commonest mode of poisoning was suicidal (53%), adopted by unintended (47%). The route of publicity was primarily oral (88%). Dermal (5%), inhalation and ocular publicity contributed 7% to the whole. The very best incidence of poisoning was because of family brokers (44.1%) adopted by medication (18.8%), agricultural pesticides (12.8%), industrial chemical substances (8.9%), animals bites and stings (4.7%), vegetation (1.7%), unknown (2.9%) and miscellaneous teams (5.6%). Family merchandise primarily comprised of pyrethroids, rodenticides, carbamates, phenyl, detergents, corrosives and so on. Medication implicated included benzodiazepines, anticonvulsants, analgesics, antihistamines, tricyclic antidepressants, thyroid hormones and oral contraceptives. Among the many agricultural pesticides, aluminium phosphide was probably the most generally consumed adopted by organochlorines, organophosphates, ethylene dibromide, herbicides and fungicides. Copper sulphate and nitrobenzene have been widespread amongst industrial chemical substances.
  • The bites and stings group comprised of snake bites, scorpion, wasp and bee stings. Poisoning because of vegetation was low, however datura was probably the most generally ingested. An alarming function of the research was the excessive incidence of poisoning in youngsters (36.5%). The age ranged from lower than 1 to 18 years and probably the most susceptible age group included youngsters from lower than 1 yr to six years. Unintentional mode was the commonest (79.7%). Intentional makes an attempt have been additionally observed (20.2%) within the age group above 12 years. The current knowledge might not give an actual image of the incidence of poisoning in India, however represents a pattern in our nation. The Poisons Info Centre performs a significant function in offering well timed administration tips together with the provision of obligatory antidotes from the not too long ago established Nationwide Antidote Financial institution, thereby serving to to avoid wasting valuable lives.

[Safety information project on drug, food and chemicals. Division of Safety Information on Drug, Food and Chemicals. National Institute of Health Sciences].

Current points on BSE(Bovine Spongiform Encephalopathy) and well being hazards attributable to antagonistic reactions of medical medication, have strongly emphasised the need for security measures to safe public well being. These points have been attributed to the delay to acquire abroad info on security and regulation, and the dearth of an sufficient system for acquirement and evaluation of such info. In an effort to develop a system the place home and worldwide security info is collected, analyzed, assessed and offered each scientifically and systematically, the Division of Chem-Bio Informatics of the Nationwide Institute of Well being Sciences was reorganized to the Division of Security Info on Drug, Meals and Chemical substances in April, 2003.
Assortment and analysis of security info on medical medication, meals and chemical substances is now centralized on the Division, which consists of 5 sections, the primary, second and third sections being newly established. The primary part assesses info on medical medication, the second part offers with meals microorganisms, and the third part focuses on chemical substances in meals. The fourth and fifth sections retain their earlier capabilities, particularly, chemical security info analysis and data community infrastructure assist throughout the institute, respectively. The aim of this paper is to explain how we are going to handle security info on drug, meals and chemical substances, specializing in the function of the three new sections.

A research of childhood poisoning at Nationwide Poisons Info Centre, All India Institute of Medical Sciences, New Delhi.

  • A retrospective evaluation of the poisoning calls acquired by the Nationwide Poisons Info Centre (NPIC) confirmed a complete of two,720 calls throughout a interval of three years (April 1999-March 2002). Poisoning in youngsters was reported in 995 calls (36.6%). The age ranged from lower than 1 yr to 18 yr and the age teams concerned have been divided into 4 classes (0-6 yr, >6-12 yr, >12-16 yr, >16-18 yr). Probably the most susceptible age group included youngsters from lower than one yr to six yr previous. Males outnumbered females (M=628, F=367).
  • Though the unintended mode was the most typical (79.7%), intentional makes an attempt have been additionally observed (20.2%) within the >12-16 yr and >16-18 yr age teams. Within the majority of circumstances, the route was oral (96.8%) adopted by dermal publicity (3.2%) comprising bites and stings. Varied varieties of brokers belonged to lessons of family merchandise (47.0%), medication (21.8%), industrial chemical substances (7.9%), agricultural pesticides (9.1%), bites and stings (3.2%), vegetation (1.5%), miscellaneous merchandise (5.3%) and unknown merchandise (4.0%). The incidence of poisoning was highest because of family merchandise comprising primarily pyrethroids, parad/thermometer mercury, rodenticides, phenyl, detergents and corrosives, and so on.
  • Poisoning because of medication primarily included anticonvulsants, thyroid hormones, benzodiazepines, analgesics and oral contraceptives. Among the many agricultural pesticides aluminium phosphide was probably the most generally consumed, adopted by organochlorines and organophosphates, and so on. Paint thinners have been widespread amongst industrial chemical substances. Bites and stings have been primarily snake bites and scorpion stings. Poisoning because of vegetation was low and Datura was generally ingested. Though these knowledge might not give an actual image of the incidence fee in our nation, because of underreporting of calls to the Centre and since the precise incidence may be greater and even variable, however they do give the pattern in India, indicating {that a} sturdy emphasis ought to be positioned on a prevention marketing campaign which may at the very least scale back the incidence of unintended pediatric poisoning.

Anti-IL-17 Antibody

ER1706-91 100ul
EUR 189
Description: Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types. Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response. They exert their biological effects through the binding of membrane-bound receptors which, in turn, initiate signal transduction cascades and elicit physiological changes in their target cell. Interleukin-17 (IL-17) and its cognate receptor, IL-17R, are an example of such a cytokine receptor pair. Originally identified as a rodent cDNA termed CTLA8, IL-17 is capable of inducing the secretion of IL-6 and IL-8 and augmenting the expression of ICAM-1 in human fibroblast cultures. The IL-17 protein exhibits a striking degree of homology with the HSV13 protein which mimics its function. The IL-17 receptor is a type I transmembrane protein 864 amino acids in length, that is highly expressed in spleen and kidney.

Anti-IL-17 antibody

PAab04224 100 ug
EUR 463.2

Anti-Human IL-17 receptor Antibody

101-M484 100 µg
EUR 399
Description: IL-17 binds to IL-17 receptors (IL-17 R), which share no homology with any known family of receptors. While the expression of IL-17 is restricted to activated T cells, IL-17 R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The amino acid sequence of human IL-17 R is 69% identical to mouse IL-17 R.

Human IL-17 protein

PRP100289-100ug 100 μg
EUR 1029
Description: Human IL-17 protein, expressed in E. coli

Human IL-17 protein

PRP100289-1mg 1 mg
EUR 7139
Description: Human IL-17 protein, expressed in E. coli

Human IL-17 protein

PRP100289-5ug 5 μg
EUR 149
Description: Human IL-17 protein, expressed in E. coli

Human IL-17 protein

PRP100290-100ug 100 μg
EUR 1029
Description: Human IL-17 protein, expressed in CHO Stable Cells

Human IL-17 protein

PRP100290-1mg 1 mg
EUR 6249
Description: Human IL-17 protein, expressed in CHO Stable Cells

Human IL-17 protein

PRP100290-5ug 5 μg
EUR 129
Description: Human IL-17 protein, expressed in CHO Stable Cells

Recombinant Human IL-17

HEILP-1702 5ug Ask for price

Recombinant Human IL-17

SJB09-03 25µg/vial
EUR 307.2

Anti-Mouse IL-17 Antibody

103-M411 100 µg
EUR 399
Description: The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

Anti-IL-17 alpha antibody

STJ93683 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-17Ralpha.
Jerry Martin