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Glypican-Mouse Monoclonal Antibody

DESCRIPTION

Common description

Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which can even be present in a secreted type. Just lately, GPC3 was recognized to be a helpful tumor marker for the prognosis of HCC, hepatoblastoma, melanoma, testicular germ cell tumors, and Wilms′ tumor. In sufferers with HCC, GPC3 was over expressed in neoplastic liver tissue and elevated in serum, however was undetectable in regular liver, benign liver, and the serum of wholesome donors.

GPC3 expression was additionally discovered to be greater in HCC liver tissue than in cirrhotic liver or liver with focal lesions akin to dysplastic nodules and areas of hepatic adenoma (HA) with malignant transformation. Within the context of testicular germ cell tumors, GPC3 expression is up-regulated in sure histologic subtypes, particularly yolk sac tumors and choriocarcinoma. A excessive stage of GPC3 expression has additionally been present in some sorts of embryonal tumors, akin to Wilms′ tumor and hepatoblastoma, with a low or undetectable expression in regular adjoining tissue. Collectively these research point out that GPC3 is a crucial tumor marker.

PROPERTIES

High quality Stage

organic supply

mouse

antibody type

tradition supernatant

antibody product kind

major antibodies

clone

1G12, monoclonal

description

For In Vitro Diagnostic Use in Choose Areas (See Chart)

type

buffered aqueous resolution

species reactivity

human

packaging

vial of 0.1 mL focus (261M-94)
vial of 0.5 mL focus (261M-95)
bottle of 1.0 mL predilute (261M-97)
vial of 1.0 mL focus (261M-96)
bottle of seven.0 mL predilute (261M-98)

producer/tradename

Cell Marque

utility(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG1

conjugate

unconjugated

management

hepatocellular carcinoma (HCC)

shipped in

moist ice

storage temp.

2-8°C

visualization

cytoplasmic

Glypican Three Monoclonal Antibody (9C2)

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Product Particular Info

MA5-17083 targets GPC3 in FACS, ICC, IHC, IF and WB purposes and reveals reactivity with Human and Mouse samples.

The MA5-17083 immunogen is purified recombinant fragment of human GPC3 expressed in E. Coli.

MA5-17083 detects GPC3 which has a predicted molecular weight of roughly 65.5kDa.

Goal Info

GPC3 is a cell floor proteoglycan that bears heparan sulfate. This protein could also be concerned within the suppression/modulation of development within the predominantly mesodermal tissues and organs, and will play a task within the modulation of IGF2 interactions with its receptor and thereby modulate its perform. Members of the glypican-related integral membrane proteoglycan household include a core protein anchored to the cytoplasmic membrane by way of a glycosyl phosphatidylinositol (GPI) linkage.

These proteins might play a task within the management of cell division, development regulation, and tumor predisposition. Deletion mutations in GPC3 are the reason for Simpson-Golabi-Behmel syndrome (SGBS), often known as Simpson dysmorphia syndrome (SDYS). SGBS is a situation characterised by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies.

Recombinant Anti-Glypican Three antibody

Key options and particulars

  • Produced recombinantly (animal-free) for top batch-to-batch consistency and long run safety of provide
  • Rabbit monoclonal [SP86] to Glypican 3
  • Appropriate for: ICC/IF, Movement Cyt, WB, IHC-P
  • Knockout validated
  • Reacts with: Human
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Artificial peptide inside Human Glypican Three aa 500 to the C-terminus (C terminal). The precise sequence is proprietary.
    Database hyperlink: P51654

  • Optimistic management

    • Human liver most cancers tissueThis antibody gave a optimistic end result when used within the following formaldehyde fastened cell traces: HepG2. ICC/IF: HepG2Flow Cyt: HepG2
  • Common notes

    This product is a recombinant monoclonal antibody, which presents a number of benefits together with:

    • – Excessive batch-to-batch consistency and reproducibility
    • – Improved sensitivity and specificity
    • – Lengthy-term safety of provide
    • – Animal-free manufacturing

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