Glypican-Mouse Monoclonal Antibody

DESCRIPTION

Common description

Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which can even be present in a secreted type. Just lately, GPC3 was recognized to be a helpful tumor marker for the prognosis of HCC, hepatoblastoma, melanoma, testicular germ cell tumors, and Wilms′ tumor. In sufferers with HCC, GPC3 was over expressed in neoplastic liver tissue and elevated in serum, however was undetectable in regular liver, benign liver, and the serum of wholesome donors.

GPC3 expression was additionally discovered to be greater in HCC liver tissue than in cirrhotic liver or liver with focal lesions akin to dysplastic nodules and areas of hepatic adenoma (HA) with malignant transformation. Within the context of testicular germ cell tumors, GPC3 expression is up-regulated in sure histologic subtypes, particularly yolk sac tumors and choriocarcinoma. A excessive stage of GPC3 expression has additionally been present in some sorts of embryonal tumors, akin to Wilms′ tumor and hepatoblastoma, with a low or undetectable expression in regular adjoining tissue. Collectively these research point out that GPC3 is a crucial tumor marker.

PROPERTIES

High quality Stage

500
100

organic supply

mouse

antibody type

tradition supernatant

antibody product kind

major antibodies

clone

1G12, monoclonal

description

For In Vitro Diagnostic Use in Choose Areas (See Chart)

type

buffered aqueous resolution

species reactivity

human

packaging

vial of 0.1 mL focus (261M-94)
vial of 0.5 mL focus (261M-95)
bottle of 1.0 mL predilute (261M-97)
vial of 1.0 mL focus (261M-96)
bottle of seven.0 mL predilute (261M-98)

producer/tradename

Cell Marque^™

utility(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG1

conjugate

unconjugated

management

hepatocellular carcinoma (HCC)

shipped in

moist ice

storage temp.

2-8°C

visualization

cytoplasmic

Glypican Three Monoclonal Antibody (9C2)

Product Particular Info

MA5-17083 targets GPC3 in FACS, ICC, IHC, IF and WB purposes and reveals reactivity with Human and Mouse samples.

The MA5-17083 immunogen is purified recombinant fragment of human GPC3 expressed in E. Coli.

MA5-17083 detects GPC3 which has a predicted molecular weight of roughly 65.5kDa.

Goal Info

GPC3 is a cell floor proteoglycan that bears heparan sulfate. This protein could also be concerned within the suppression/modulation of development within the predominantly mesodermal tissues and organs, and will play a task within the modulation of IGF2 interactions with its receptor and thereby modulate its perform. Members of the glypican-related integral membrane proteoglycan household include a core protein anchored to the cytoplasmic membrane by way of a glycosyl phosphatidylinositol (GPI) linkage.

These proteins might play a task within the management of cell division, development regulation, and tumor predisposition. Deletion mutations in GPC3 are the reason for Simpson-Golabi-Behmel syndrome (SGBS), often known as Simpson dysmorphia syndrome (SDYS). SGBS is a situation characterised by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies.

Recombinant Anti-Glypican Three antibody

Key options and particulars

Produced recombinantly (animal-free) for top batch-to-batch consistency and long run safety of provide
Rabbit monoclonal [SP86] to Glypican 3
Appropriate for: ICC/IF, Movement Cyt, WB, IHC-P
Knockout validated
Reacts with: Human

Species reactivity

Reacts with: Human
Immunogen

Artificial peptide inside Human Glypican Three aa 500 to the C-terminus (C terminal). The precise sequence is proprietary.
Database hyperlink: P51654
Optimistic management
- Human liver most cancers tissueThis antibody gave a optimistic end result when used within the following formaldehyde fastened cell traces: HepG2. ICC/IF: HepG2Flow Cyt: HepG2

Common notes

This product is a recombinant monoclonal antibody, which presents a number of benefits together with:

– Excessive batch-to-batch consistency and reproducibility
– Improved sensitivity and specificity
– Lengthy-term safety of provide
– Animal-free manufacturing

Human PCPE-1 AssayLite™ Antibody (FITC Conjugate)
32506-05141	AssayPro	150 ug	EUR 370

OKRC00795-96W - PCPE-1 ELISA Kit (Human)
OKRC00795-96W	Aviva Systems Biology	96Wells	EUR 600

Human PCPE-1 AssayLite™ Antibody (PerCP Conjugate)
32506-05171	AssayPro	150 ug	EUR 410

Human Procollagen C Proteinase Enhancer 1(PCPE-1)ELISA Kit
YLA3898HU-48T	Shanghai YL Biotech	48T	Ask for price

Human Procollagen C Proteinase Enhancer 1(PCPE-1)ELISA Kit
YLA3898HU-96T	Shanghai YL Biotech	96T	Ask for price

Procollagen C Proteinase Enhancer 1 (PCPE1) Polyclonal Antibody (Mouse)
4-PAB316Mu01	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price	100ul 10ml 1ml 200ul 20ul

Description: A Rabbit polyclonal antibody against Mouse Procollagen C Proteinase Enhancer 1 (PCPE1)

Mouse PCPE1 ELISA Kit
EMP0075	Abclonal	96Tests	EUR 625.2

Procollagen C Proteinase Enhancer 1 (PCPE1) Polyclonal Antibody (Mouse), PE
4-PAB316Mu01-PE	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price	100ul 10ml 1ml 200ul 20ul

Description: A Rabbit polyclonal antibody against Mouse Procollagen C Proteinase Enhancer 1 (PCPE1). This antibody is labeled with PE.

Mouse PCPE1(Procollagen C Proteinase Enhancer 1) ELISA Kit
ELK3765-48T	ELK Biotech	48T	Ask for price

Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse PCPE1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse PCPE1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse PCPE1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse PCPE1 in the samples is then determined by comparing the OD of the samples to the standard curve.

Mouse PCPE1(Procollagen C Proteinase Enhancer 1) ELISA Kit
ELK3765-96T	ELK Biotech	96T	Ask for price

Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse PCPE1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse PCPE1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse PCPE1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse PCPE1 in the samples is then determined by comparing the OD of the samples to the standard curve.

Procollagen C Proteinase Enhancer 1 (PCPE1) Polyclonal Antibody (Mouse), APC
4-PAB316Mu01-APC	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price	100ul 10ml 1ml 200ul 20ul

Description: A Rabbit polyclonal antibody against Mouse Procollagen C Proteinase Enhancer 1 (PCPE1). This antibody is labeled with APC.

Procollagen C Proteinase Enhancer 1 (PCPE1) Polyclonal Antibody (Mouse), Cy3
4-PAB316Mu01-Cy3	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price	100ul 10ml 1ml 200ul 20ul

Description: A Rabbit polyclonal antibody against Mouse Procollagen C Proteinase Enhancer 1 (PCPE1). This antibody is labeled with Cy3.

Procollagen C Proteinase Enhancer 1 (PCPE1) Polyclonal Antibody (Mouse), FITC
4-PAB316Mu01-FITC	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price	100ul 10ml 1ml 200ul 20ul

Description: A Rabbit polyclonal antibody against Mouse Procollagen C Proteinase Enhancer 1 (PCPE1). This antibody is labeled with FITC.

Procollagen C Proteinase Enhancer 1 (PCPE1) Polyclonal Antibody (Mouse), HRP
4-PAB316Mu01-HRP	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price	100ul 10ml 1ml 200ul 20ul

Description: A Rabbit polyclonal antibody against Mouse Procollagen C Proteinase Enhancer 1 (PCPE1). This antibody is labeled with HRP.

Procollagen C Proteinase Enhancer 1 (PCPE1) Polyclonal Antibody (Human, Mouse)
4-PAB316Hu02	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price	100ul 10ml 1ml 200ul 20ul

Description: A Rabbit polyclonal antibody against Human, Mouse Procollagen C Proteinase Enhancer 1 (PCPE1)

ELISA kit for Mouse PCPE1 (Procollagen C Proteinase Enhancer 1)
ELK3765	ELK Biotech	1 plate of 96 wells	EUR 518.4

Description: A sandwich ELISA kit for detection of Procollagen C Proteinase Enhancer 1 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Mouse Procollagen C Proteinase Enhancer 1 (PCPE1) Protein
20-abx068670	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 10 ug 1 mg 200 ug 50 ug

Procollagen C Proteinase Enhancer 1 (PCPE1) Polyclonal Antibody (Human, Mouse), APC
4-PAB316Hu02-APC	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price	100ul 10ml 1ml 200ul 20ul

Description: A Rabbit polyclonal antibody against Human, Mouse Procollagen C Proteinase Enhancer 1 (PCPE1). This antibody is labeled with APC.

Procollagen C Proteinase Enhancer 1 (PCPE1) Polyclonal Antibody (Human, Mouse), Cy3
4-PAB316Hu02-Cy3	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price	100ul 10ml 1ml 200ul 20ul

Description: A Rabbit polyclonal antibody against Human, Mouse Procollagen C Proteinase Enhancer 1 (PCPE1). This antibody is labeled with Cy3.

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