Reduced-intensity versus myeloablative conditioning in cord blood transplantation for AML (40-60 years) across highly mismatched HLA barriers – On behalf of Eurocord and the Cellular Therapy & Immunobiology Working Party (CTIWP) of EBMT
The usage of myeloablative conditioning (MAC) in umbilical wire blood transplantation (UCBT) has been related to excessive non-relapse mortality (NRM) in sufferers >40 years, particularly these having a excessive HLA disparity, thus limiting wider functions. We hypothesized that the NRM benefit of decreased depth conditioning (RIC) and better GVL related to higher HLA disparities would increase its use for sufferers (40-60 years) with out compromising efficacy, and in contrast outcomes between RIC versus MAC regimens.
288 sufferers aged 40 to 60 years, with de novo AML, receiving UCBT with at the very least 2 HLA mismatches with RIC (n=166) or MAC (n=122) regimens have been included.
As in comparison with RIC, the MAC cohort included comparatively youthful sufferers, having acquired extra single UCBT, with decrease whole nucleated cell counts, and extra in vivo T-cell depletion. Median time to neutrophil engraftment, infections (bacterial, viral and fungal), in addition to grade II-IV acute and persistent graft-versus-host illness have been related in each teams.
Within the multivariate evaluation, total survival (HR-0.98, p=0.9), NRM (HR-0.68, p=0.2) and relapse (HR- 1.24, p=0.5) weren’t totally different between RIC and MAC. Refractory illness was related to worse survival. Outcomes of UBCT for sufferers 40-60 years having ≥2 HLA mismatches are comparable after RIC or MAC routine.
The B cell immunobiology that underlies CNS autoantibody-mediated ailments
A quickly increasing and clinically distinct group of CNS ailments are attributable to pathogenic autoantibodies that focus on neuroglial floor proteins. Regardless of immunotherapy, sufferers with these neuroglial floor autoantibody (NSAb)-mediated ailments usually expertise scientific relapse, excessive charges of long-term morbidity and opposed results from the obtainable drugs.
- Basically, the autoantigen-specific B cell lineage results in manufacturing of the pathogenic autoantibodies.
- These autoantigen-specific B cells have been constantly recognized within the circulation of sufferers with NSAb-mediated ailments, accompanied by excessive serum ranges of autoantigen-specific antibodies.
- Early proof means that these cells evade well-characterized B cell tolerance checkpoints.
- Nearer to the location of pathology, cerebrospinal fluid from sufferers with NSAb-mediated ailments comprises excessive ranges of autoantigen-specific B cells which can be more likely to account for the intrathecal synthesis of those autoantibodies.
- The traits of their immunoglobulin genes provide insights into the underlying immunobiology. On this Overview, we summarize the rising information of B cells throughout the NSAb-mediated ailments.
- We evaluation the proof for the relative contributions of germinal centres and long-lived plasma cells as sources of autoantibodies, focus on information that point out migration of B cells into the CNS and summarize insights into the underlying B cell pathogenesis which can be supplied by therapeutic results.
Coccidiosis: current developments within the immunobiology of Eimeria species, preventive measures, and the significance of vaccination as a management device towards these Apicomplexan parasites
Coccidiosis, attributable to parasites of the genus Eimeria, might be the most costly parasitic illness of poultry. Species of Eimeria are ubiquitous the place poultry are raised and are identified to trigger drastic reductions in efficiency and induce mortality, thereby affecting the general well being standing of poultry. Chemotherapy has been the predominant type of illness management for a few years, regardless that vaccination is steadily gaining significance as a possible management methodology.
The target of this evaluation is to spotlight current developments in understanding the position of host immunity towards coccidiosis. As well as, execs and cons related to chemotherapy and the position of vaccination as an more and more common illness management methodology are mentioned.
Lastly, the position performed by recombinant vaccines as a possible vaccination device is highlighted. With curiosity rising quickly in understanding host-parasite biology, current developments in designing recombinant vaccines and potential epitopes which have proven promise are talked about.
Translating the Immunobiology of SBRT to Novel Therapeutic Combos for Superior Prostate Most cancers
Stereotactic physique radiotherapy (SBRT) is an more and more used radiation modality for the therapy of each localized and metastatic prostate most cancers. Substantial information means that prostate most cancers could also be extra delicate to increased doses of radiation per fraction as a consequence of its low α/β ratio.
This elevated sensitivity raises necessary questions as to how SBRT needs to be mixed with systemic remedy for clinically vital prostate most cancers, together with whether or not androgen deprivation remedy retains its useful results when mixed with SBRT.
Moreover, pre-clinical and scientific information recommend pronounced immunomodulatory results of SBRT, together with noticed enhancements in T cell priming and trafficking. These information assist investigational methods combining SBRT with immunotherapy.
Right here we intention to evaluation the info for using SBRT in each the native and metastatic illness settings in addition to ongoing translational and scientific analysis inspecting combos with ADT, immunotherapy and different focused brokers.
Immunobiology and structural biology of AIM2 inflammasome
Absent in melanoma 2 (AIM2) is a cytoplasmic sensor that upon recognizing double-stranded DNA assembles with apoptosis-associated speck-like protein containing a CARD (ASC) and procaspase-1 to type the multi-protein advanced AIM2 inflammasome.
Double-stranded DNA from bacterial, viral, or host mobile origins triggers AIM2 inflammasome meeting and activation, finally leading to secretion of proinflammatory cytokines and pyroptotic cell dying with a purpose to remove microbial an infection. Many pathogens subsequently evade or suppress AIM2 inflammasome to ascertain an infection.
However, AIM2 activation is tightly managed by a number of mobile elements to forestall autoinflammation. Intensive structural research have captured the molecular particulars of a number of steps in AIM2 inflammasome meeting.
The constructions collectively revealed a nucleated polymerization mechanism that not solely pervades every step of AIM2 inflammasome meeting, but in addition underlies meeting of different inflammasomes and complexes in immune signaling.
On this article, we briefly evaluation the identification of AIM2 as a cytoplasmic DNA sensor, summarize the significance of AIM2 inflammasome in infections and ailments, and focus on the molecular mechanisms of AIM2 meeting, activation, and regulation utilizing current mobile, biochemical, and structural outcomes.
 6X His tag monoclonal antibody |
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| FNSA-0019 | FN Test | 500 uL | EUR 341.4 |
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Description: 6X His tag monoclonal antibody secondary antibody |
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 ELISA Test Kit) Tetrodotoxin (TTX) ELISA Test Kit |
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| DEIANJ48 | Creative Diagnostics | 96T | EUR 1625 |
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Description: This test kit is for the quantitative detection of Tetrodotoxin in the tissue, liver, fish. |
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 (His tag)) PDHE2 protein (GST tag) (His tag) |
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| 80-1378 | Fitzgerald | 1 mg | EUR 565 |
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Description: PDHE2 protein (GST tag) (His tag) |
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 (His tag)) SLA protein (GST tag) (His tag) |
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| 80-1380 | Fitzgerald | 1 mg | EUR 597 |
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Description: Purified recombinant SLA protein (GST tag) (His tag) |
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 (His tag)) TROVE2 protein (GST tag) (His tag) |
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| 80-1383 | Fitzgerald | 1 mg | EUR 619 |
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Description: Purified recombinant TROVE2 (Ro60) protein (GST tag) (His tag) |
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 Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit |
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| CAS400A-KIT | SBI | 1 kit (10 rxn) | EUR 1110 |
) MB protein (His tag) |
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| 80R-1634 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human MB protein |
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) MAP1LC3B protein (His tag) |
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| 80R-1635 | Fitzgerald | 100 ug | EUR 349 |
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Description: Purified recombinant Human MAP1LC3B protein |
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) RAB7A protein (His tag) |
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| 80R-1636 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human RAB7A protein |
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) Ecotin protein (His tag) |
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| 80R-1637 | Fitzgerald | 50 ug | EUR 305 |
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Description: Purified recombinant E.coli Ecotin protein |
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) AIF1L protein (His tag) |
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| 80R-1638 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human AIF1L protein |
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) AK4 protein (His tag) |
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| 80R-1639 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human AK4 protein |
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) BDH2 protein (His tag) |
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| 80R-1640 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human BDH2 protein |
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) BPNT1 protein (His tag) |
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| 80R-1641 | Fitzgerald | 50 ug | EUR 305 |
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Description: Purified recombinant Human BPNT1 protein |
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) DCUN1D1 protein (His tag) |
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| 80R-1642 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human DCUN1D1 protein |
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) GABARAPL2 protein (His tag) |
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| 80R-1643 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human GABARAPL2 protein |
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) GCA protein (His tag) |
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| 80R-1644 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human GCA protein |
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) GGCT protein (His tag) |
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| 80R-1645 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human GGCT protein |
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) GRAP2 protein (His tag) |
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| 80R-1646 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human GRAP2 protein |
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) NME3 protein (His tag) |
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| 80R-1647 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human NME3 protein |
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) NUDT2 protein (His tag) |
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| 80R-1648 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human NUDT2 protein |
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) RAP1B protein (His tag) |
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| 80R-1649 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human RAP1B protein |
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) TXNL1 protein (His tag) |
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| 80R-1650 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human TXNL1 protein |
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) PFDN4 protein (His tag) |
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| 80R-1651 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human PFDN4 protein |
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) UBE2K protein (His tag) |
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| 80R-1652 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human UBE2K protein |
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) NCALD protein (His tag) |
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| 80R-1653 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human NCALD protein |
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) DDIT4 protein (His tag) |
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| 80R-1654 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human DDIT4 protein |
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) TFAM protein (His tag) |
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| 80R-1655 | Fitzgerald | 10 ug | EUR 305 |
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Description: Purified recombinant Human TFAM protein |
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) TAF9 protein (His tag) |
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| 80R-1656 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human TAF9 protein |
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) SUGT1 protein (His tag) |
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| 80R-1657 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human SUGT1 protein |
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) RAB1A protein (His tag) |
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| 80R-1658 | Fitzgerald | 50 ug | EUR 305 |
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Description: Purified recombinant Human RAB1A protein |
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) PPP3R1 protein (His tag) |
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| 80R-1659 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human PPP3R1 protein |
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) EIF1AY protein (His tag) |
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| 80R-1660 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human EIF1AY protein |
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) ATG5 protein (His tag) |
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| 80R-1661 | Fitzgerald | 50 ug | EUR 305 |
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Description: Purified recombinant Human ATG5 protein |
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) FADH1 protein (His tag) |
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| 80R-1662 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human FADH1 protein |
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) PEF1 protein (His tag) |
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| 80R-1663 | Fitzgerald | 50 ug | EUR 305 |
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Description: Purified recombinant Human PEF1 protein |
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) MLF1 protein (His tag) |
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| 80R-1664 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human MLF1 protein |
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) RAB21 protein (His tag) |
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| 80R-1665 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human RAB21 protein |
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) LCN2 protein (His tag) |
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| 80R-1666 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human LCN2 protein |
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) CIB2 protein (His tag) |
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| 80R-1667 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human CIB2 protein |
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) NMT2 protein (His tag) |
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| 80R-1668 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human NMT2 protein |
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) DNAJC19 protein (His tag) |
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| 80R-1669 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human DNAJC19 protein |
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) DHFR protein (His tag) |
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| 80R-1670 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant mouse DHFR protein |
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) IMPA2 protein (His tag) |
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| 80R-1671 | Fitzgerald | 50 ug | EUR 305 |
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Description: Purified recombinant Human IMPA2 protein |
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) BCAS2 protein (His tag) |
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| 80R-1672 | Fitzgerald | 10 ug | EUR 305 |
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Description: Purified recombinant Human BCAS2 protein |
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) BLNK protein (His tag) |
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| 80R-1673 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human BLNK protein |
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) CCL3L1 protein (His tag) |
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| 80R-1674 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human CCL3L1 protein |
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) CCL20 protein (His tag) |
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| 80R-1675 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human CCL20 protein |
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) RAB6B protein (His tag) |
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| 80R-1676 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human RAB6B protein |
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) SNRPE protein (His tag) |
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| 80R-1677 | Fitzgerald | 10 ug | EUR 305 |
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Description: Purified recombinant Human SNRPE protein |
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) SF3B14 protein (His tag) |
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| 80R-1678 | Fitzgerald | 50 ug | EUR 305 |
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Description: Purified recombinant Human SF3B14 protein |
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) RERG protein (His tag) |
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| 80R-1679 | Fitzgerald | 50 ug | EUR 397 |
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Description: Purified recombinant Human RERG protein |
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) NUDT3 protein (His tag) |
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| 80R-1680 | Fitzgerald | 50 ug | EUR 305 |
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Description: Purified recombinant Human NUDT3 protein |
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) MYL9 protein (His tag) |
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| 80R-1681 | Fitzgerald | 50 ug | EUR 305 |
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Description: Purified recombinant Human MYL9 protein |
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) CAPS protein (His tag) |
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| 80R-1682 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human CAPS protein |
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) RPS14 protein (His tag) |
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| 80R-1683 | Fitzgerald | 10 ug | EUR 305 |
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Description: Purified recombinant Human RPS14 protein |
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) LYPLA2 protein (His tag) |
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| 80R-1684 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human LYPLA2 protein |
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) ENOPH1 protein (His tag) |
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| 80R-1685 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human ENOPH1 protein |
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) ACYP1 protein (His tag) |
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| 80R-1686 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human ACYP1 protein |
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) BATF protein (His tag) |
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| 80R-1687 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human BATF protein |
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) CCL14 protein (His tag) |
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| 80R-1688 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human CCL14 protein |
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) eFIMC protein (His tag) |
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| 80R-1689 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant E.coli eFIMC protein |
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) ERH protein (His tag) |
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| 80R-1690 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human ERH protein |
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) MESDC2 protein (His tag) |
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| 80R-1691 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human MESDC2 protein |
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) NUDT16L1 protein (His tag) |
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| 80R-1692 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human NUDT16L1 protein |
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) NUDT21 protein (His tag) |
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| 80R-1693 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human NUDT21 protein |
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) RBP7 protein (His tag) |
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| 80R-1694 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human RBP7 protein |
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) SNRPD2 protein (His tag) |
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| 80R-1695 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human SNRPD2 protein |
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) TAGLN2 protein (His tag) |
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| 80R-1696 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human TAGLN2 protein |
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