Reduced-intensity versus myeloablative conditioning in cord blood transplantation for AML (40-60 years) across highly mismatched HLA barriers – On behalf of Eurocord and the Cellular Therapy & Immunobiology Working Party (CTIWP) of EBMT
The usage of myeloablative conditioning (MAC) in umbilical wire blood transplantation (UCBT) has been related to excessive non-relapse mortality (NRM) in sufferers >40 years, particularly these having a excessive HLA disparity, thus limiting wider functions. We hypothesized that the NRM benefit of decreased depth conditioning (RIC) and better GVL related to higher HLA disparities would increase its use for sufferers (40-60 years) with out compromising efficacy, and in contrast outcomes between RIC versus MAC regimens.
288 sufferers aged 40 to 60 years, with de novo AML, receiving UCBT with at the very least 2 HLA mismatches with RIC (n=166) or MAC (n=122) regimens have been included.
As in comparison with RIC, the MAC cohort included comparatively youthful sufferers, having acquired extra single UCBT, with decrease whole nucleated cell counts, and extra in vivo T-cell depletion. Median time to neutrophil engraftment, infections (bacterial, viral and fungal), in addition to grade II-IV acute and persistent graft-versus-host illness have been related in each teams.
Within the multivariate evaluation, total survival (HR-0.98, p=0.9), NRM (HR-0.68, p=0.2) and relapse (HR- 1.24, p=0.5) weren’t totally different between RIC and MAC. Refractory illness was related to worse survival. Outcomes of UBCT for sufferers 40-60 years having ≥2 HLA mismatches are comparable after RIC or MAC routine.
The B cell immunobiology that underlies CNS autoantibody-mediated ailments
A quickly increasing and clinically distinct group of CNS ailments are attributable to pathogenic autoantibodies that focus on neuroglial floor proteins. Regardless of immunotherapy, sufferers with these neuroglial floor autoantibody (NSAb)-mediated ailments usually expertise scientific relapse, excessive charges of long-term morbidity and opposed results from the obtainable drugs.
- Basically, the autoantigen-specific B cell lineage results in manufacturing of the pathogenic autoantibodies.
- These autoantigen-specific B cells have been constantly recognized within the circulation of sufferers with NSAb-mediated ailments, accompanied by excessive serum ranges of autoantigen-specific antibodies.
- Early proof means that these cells evade well-characterized B cell tolerance checkpoints.
- Nearer to the location of pathology, cerebrospinal fluid from sufferers with NSAb-mediated ailments comprises excessive ranges of autoantigen-specific B cells which can be more likely to account for the intrathecal synthesis of those autoantibodies.
- The traits of their immunoglobulin genes provide insights into the underlying immunobiology. On this Overview, we summarize the rising information of B cells throughout the NSAb-mediated ailments.
- We evaluation the proof for the relative contributions of germinal centres and long-lived plasma cells as sources of autoantibodies, focus on information that point out migration of B cells into the CNS and summarize insights into the underlying B cell pathogenesis which can be supplied by therapeutic results.
Coccidiosis: current developments within the immunobiology of Eimeria species, preventive measures, and the significance of vaccination as a management device towards these Apicomplexan parasites
Coccidiosis, attributable to parasites of the genus Eimeria, might be the most costly parasitic illness of poultry. Species of Eimeria are ubiquitous the place poultry are raised and are identified to trigger drastic reductions in efficiency and induce mortality, thereby affecting the general well being standing of poultry. Chemotherapy has been the predominant type of illness management for a few years, regardless that vaccination is steadily gaining significance as a possible management methodology.
The target of this evaluation is to spotlight current developments in understanding the position of host immunity towards coccidiosis. As well as, execs and cons related to chemotherapy and the position of vaccination as an more and more common illness management methodology are mentioned.
Lastly, the position performed by recombinant vaccines as a possible vaccination device is highlighted. With curiosity rising quickly in understanding host-parasite biology, current developments in designing recombinant vaccines and potential epitopes which have proven promise are talked about.
Translating the Immunobiology of SBRT to Novel Therapeutic Combos for Superior Prostate Most cancers
Stereotactic physique radiotherapy (SBRT) is an more and more used radiation modality for the therapy of each localized and metastatic prostate most cancers. Substantial information means that prostate most cancers could also be extra delicate to increased doses of radiation per fraction as a consequence of its low α/β ratio.
This elevated sensitivity raises necessary questions as to how SBRT needs to be mixed with systemic remedy for clinically vital prostate most cancers, together with whether or not androgen deprivation remedy retains its useful results when mixed with SBRT.
Moreover, pre-clinical and scientific information recommend pronounced immunomodulatory results of SBRT, together with noticed enhancements in T cell priming and trafficking. These information assist investigational methods combining SBRT with immunotherapy.
Right here we intention to evaluation the info for using SBRT in each the native and metastatic illness settings in addition to ongoing translational and scientific analysis inspecting combos with ADT, immunotherapy and different focused brokers.
Immunobiology and structural biology of AIM2 inflammasome
Absent in melanoma 2 (AIM2) is a cytoplasmic sensor that upon recognizing double-stranded DNA assembles with apoptosis-associated speck-like protein containing a CARD (ASC) and procaspase-1 to type the multi-protein advanced AIM2 inflammasome.
Double-stranded DNA from bacterial, viral, or host mobile origins triggers AIM2 inflammasome meeting and activation, finally leading to secretion of proinflammatory cytokines and pyroptotic cell dying with a purpose to remove microbial an infection. Many pathogens subsequently evade or suppress AIM2 inflammasome to ascertain an infection.
However, AIM2 activation is tightly managed by a number of mobile elements to forestall autoinflammation. Intensive structural research have captured the molecular particulars of a number of steps in AIM2 inflammasome meeting.
The constructions collectively revealed a nucleated polymerization mechanism that not solely pervades every step of AIM2 inflammasome meeting, but in addition underlies meeting of different inflammasomes and complexes in immune signaling.
On this article, we briefly evaluation the identification of AIM2 as a cytoplasmic DNA sensor, summarize the significance of AIM2 inflammasome in infections and ailments, and focus on the molecular mechanisms of AIM2 meeting, activation, and regulation utilizing current mobile, biochemical, and structural outcomes.
 6X His tag monoclonal antibody |
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| FNSA-0019 | FN Test | 500 uL | EUR 341.4 |
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Description: 6X His tag monoclonal antibody secondary antibody |
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 ELISA Test Kit) Tetrodotoxin (TTX) ELISA Test Kit |
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| DEIANJ48 | Creative Diagnostics | 96T | EUR 1625 |
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Description: This test kit is for the quantitative detection of Tetrodotoxin in the tissue, liver, fish. |
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 Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit |
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| CAS400A-KIT | SBI | 1 kit (10 rxn) | EUR 1110 |
 (His tag)) PDHE2 protein (GST tag) (His tag) |
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| 80-1378 | Fitzgerald | 1 mg | EUR 565 |
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Description: PDHE2 protein (GST tag) (His tag) |
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 (His tag)) SLA protein (GST tag) (His tag) |
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| 80-1380 | Fitzgerald | 1 mg | EUR 597 |
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Description: Purified recombinant SLA protein (GST tag) (His tag) |
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 (His tag)) TROVE2 protein (GST tag) (His tag) |
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| 80-1383 | Fitzgerald | 1 mg | EUR 619 |
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Description: Purified recombinant TROVE2 (Ro60) protein (GST tag) (His tag) |
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 ELISA test) TSH (Thyrotrophin) ELISA test |
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| 14 | Biobase | 96T/Box | Ask for price |
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Description: ELISA based test for quantitative detection of TSH (Thyrotrophin) |
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 ELISA test) T3 (Triiodothyronine) ELISA test |
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| 15 | Biobase | 96T/Box | Ask for price |
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Description: ELISA based test for quantitative detection of T3 (Triiodothyronine) |
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 ELISA test) T4 (Thyroxine) ELISA test |
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| 16 | Biobase | 96T/Box | Ask for price |
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Description: ELISA based test for quantitative detection of T4 (Thyroxine) |
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 ELISA test) TESTO (Testosterone) ELISA test |
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| 19 | Biobase | 96T/Box | Ask for price |
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Description: ELISA based test for quantitative detection of O (osterone) |
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 CA72-4 ELISA test |
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| 24 | Biobase | 96T/Box | Ask for price |
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Description: ELISA based test for quantitative detection of CA72-4 |
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 ELISA test) PRL (Prolactin) ELISA test |
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| 4 | Biobase | 96T/Box | Ask for price |
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Description: ELISA based test for quantitative detection of PRL (Prolactin) |
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 ELISA test) E2 (Estradiol) ELISA test |
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| 5 | Biobase | 96T/Box | Ask for price |
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Description: ELISA based test for quantitative detection of E2 (Estradiol) |
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 ELISA test) FERR ( Ferritin) ELISA test |
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| 7 | Biobase | 96T/Box | Ask for price |
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Description: ELISA based test for quantitative detection of FERR ( Ferritin) |
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 HBcAb Sandwich ELISA test |
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| 95 | Biobase | 96T/Box | Ask for price |
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Description: ELISA based test for quantitative detection of HBcAb Sandwich |
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 PreS2-Ag ELISA test |
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| 96 | Biobase | 96T/Box | Ask for price |
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Description: ELISA based test for quantitative detection of PreS2-Ag |
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 NDV rapid test kit |
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| RG15-03 | Bionote | 1 box | EUR 139.05 |
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Description: Please check the datasheet of NDV rapid test kit before using the test. |
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 Melamine Rapid Test Kit |
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| abx092011-50tests | Abbexa | 50 tests | EUR 370 |
 Accu-Tell COVID-19 IgG/IgM Rapid Test |
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| GEN-B352-20tests | Accu test | 20 tests | EUR 236 |
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Description: A rapid test for detection of antibodies (IgG and IgM) for 2019-nCoV, the novel Coronavirus from the Wuhan strain. The test is easy to perform, takes 10 minutes to provide reliable results and is higly specific to the 2019-nCoV Coronavirus. |
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Accu-Tell COVID-19 IgG/IgM Rapid Test |
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| GEN-B352-40tests | Accu test | 40 tests | EUR 321 |
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Description: A rapid test for detection of antibodies (IgG and IgM) for 2019-nCoV, the novel Coronavirus from the Wuhan strain. The test is easy to perform, takes 10 minutes to provide reliable results and is higly specific to the 2019-nCoV Coronavirus. |
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 Frit Kit |
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| FRIT-KIT | Next Advance | 1each | EUR 124 |
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Description: Kit to create frits in capillaries. Includes formamide, Kasil-1, Kasil-1624 and a cleaving tool. |
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 His-tag Purification Kit |
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| abx299036-4U | Abbexa | 4 U | EUR 356 |
 DYKDDDDK-Tag Protein ELISA Kit |
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| E4700-100 | Biovision | EUR 436 | |
 Column Packing Kit |
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| PACK-KIT | Next Advance | 1pack | EUR 1035 |
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Description: Column packing kit for pressure cells. Includes: HPREG regulator, TBNG10 tubing, CAP-75 capillary, and STRB5X2 stir bar. |
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 Myostatin, His-Tag Protein |
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| 20-abx262128 | Abbexa |
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) EBNA1 protein (His tag) |
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| 80-1340 | Fitzgerald | 100 ug | EUR 241 |
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Description: Purified recombinant EBNA1 protein (His tag) |
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) ompP2 protein (His tag) |
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| 80-1349 | Fitzgerald | 100 ug | EUR 241 |
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Description: Purified recombinant ompP2 protein (His tag) |
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) GARS protein (His tag) |
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| 80-1374 | Fitzgerald | 1 mg | EUR 565 |
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Description: Purified recombinant GARS/GlyRS protein (His tag) |
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) JO1 protein (His tag) |
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| 80-1375 | Fitzgerald | 1 mg | EUR 565 |
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Description: Purified recombinant JO1 protein (His tag) |
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) IARS protein (His tag) |
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| 80-1377 | Fitzgerald | 1 mg | EUR 2120 |
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Description: Purified recombinant IARS (OJ) protein (His tag) |
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) tTG protein (His tag) |
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| 80-1379 | Fitzgerald | 1 mg | EUR 586 |
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Description: Purified recombinant tTG protein (His tag) |
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) PSIP1 protein (His tag) |
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| 80-1381 | Fitzgerald | 1 mg | EUR 1753 |
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Description: Purified recombinant PSIP1 (DSF70) protein (His tag) |
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) TPO protein (His tag) |
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| 80-1382 | Fitzgerald | 1 mg | EUR 1277 |
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Description: Purified recombinant TPO protein (His tag) |
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) TRIM21 protein (His tag) |
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| 80-1385 | Fitzgerald | 1 mg | EUR 565 |
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Description: Purified recombinant TRIM21 (Ro52) protein (His tag) |
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) TG3 protein (His tag) |
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| 80-1386 | Fitzgerald | 1 mg | EUR 1321 |
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Description: Purified recombinant Transglutaminase 3 (TG3) protein (His tag) |
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) SP100 protein (His tag) |
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| 80-1387 | Fitzgerald | 1 mg | EUR 565 |
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Description: Purified recombinant SP100 protein (His tag) |
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) PHGDH protein (His tag) |
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| 80-1603 | Fitzgerald | 50 ug | EUR 1482 |
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Description: Purified recombinant PHGDH protein (His tag) |
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) HSP90 protein (His tag) |
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| 80R-1003 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human HSP90 protein |
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) CEBPalpha protein (His tag) |
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| 80R-1005 | Fitzgerald | 100 ug | EUR 224 |
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Description: Purified recombinant Human CEBPalpha protein |
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) MIF protein (His tag) |
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| 80R-1007 | Fitzgerald | 100 ug | EUR 224 |
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Description: Purified recombinant Human MIF protein |
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) TPD52L1 protein (His tag) |
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| 80R-1009 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human TPD52L1 protein |
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) HSP70 protein (His tag) |
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| 80R-1011 | Fitzgerald | 100 ug | EUR 300 |
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Description: Purified recombinant Human HSP70 protein |
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) SNAP25 protein (His tag) |
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| 80R-1012 | Fitzgerald | 100 ug | EUR 224 |
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Description: Purified recombinant Human SNAP25 protein |
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) BHMT protein (His tag) |
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| 80R-1013 | Fitzgerald | 100 ug | EUR 224 |
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Description: Purified recombinant Human BHMT protein |
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) DMGO protein (His tag) |
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| 80R-1014 | Fitzgerald | 100 ug | EUR 224 |
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Description: Purified recombinant Arthrobacter globiformis DMGO protein |
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) PARK7 protein (His tag) |
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| 80R-1015 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human PARK7 protein |
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) Geminin protein (His tag) |
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| 80R-1016 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human Geminin protein |
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) IRF1 protein (His tag) |
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| 80R-1026 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human IRF1 protein |
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) Vaspin protein (His tag) |
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| 80R-1027 | Fitzgerald | 100 ug | EUR 586 |
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Description: Purified recombinant Human Vaspin protein |
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) Visfatin protein (His tag) |
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| 80R-1028 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Mouse Visfatin protein |
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) PAI1 protein (His tag) |
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| 80R-1029 | Fitzgerald | 100 ug | EUR 349 |
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Description: Purified recombinant Human PAI1 protein |
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) FABP1 protein (His tag) |
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| 80R-1030 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human FABP1 protein |
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) IRF2 protein (His tag) |
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| 80R-1032 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human IRF2 protein |
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) mAdiponectin protein (His tag) |
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| 80R-1033 | Fitzgerald | 100 ug | EUR 457 |
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Description: Purified recombinant Mouse mAdiponectin protein |
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) IL3 protein (His tag) |
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| 80R-1035 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human IL3 protein |
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) IL15 protein (His tag) |
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| 80R-1036 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human IL15 protein |
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) BLyS protein (His tag) |
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| 80R-1037 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human BLyS protein |
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) RARalpha protein (His tag) |
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| 80R-1038 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human RARalpha protein |
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) CIB1 protein (His tag) |
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| 80R-1039 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human CIB1 protein |
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) IPP1 protein (His tag) |
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| 80R-1040 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human IPP1 protein |
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) HSP60 protein (His tag) |
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| 80R-1043 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human HSP60 protein |
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Visfatin protein (His tag) |
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| 80R-1045 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human Visfatin protein |
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) IL16 protein (His tag) |
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| 80R-1046 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Human IL16 protein |
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) CNTF protein (His tag) |
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| 80R-1047 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human CNTF protein |
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) PPID protein (His tag) |
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| 80R-1048 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human PPID protein |
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) Nucb2 protein (His tag) |
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| 80R-1051 | Fitzgerald | 100 ug | EUR 305 |
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Description: Purified recombinant Mouse Nucb2 protein |
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) PPM1G protein (His tag) |
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| 80R-1052 | Fitzgerald | 100 ug | EUR 224 |
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Description: Purified recombinant Human PPM1G protein |
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) CSTB protein (His tag) |
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| 80R-1053 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human CSTB protein |
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) HSF1 protein (His tag) |
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| 80R-1054 | Fitzgerald | 100 ug | EUR 397 |
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Description: Purified recombinant Human HSF1 protein |
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